1. Travelers are paying more to fly to Mexico and the Caribbean this year
  2. Images released of 12 men wanted over FA Cup violence before Millwall’s win over Everton last month
  3. Would you eat meat from a gene-edited animal?
  4. Alien news: UFO ‘not visible with naked eye’ filmed above Texas
  5. Border crossings at record lows as Trump moves to declare national emergency to build wall
  6. FTSE LIVE: RBS profits double; Premier Foods scraps Ambrosia sale; Pound under pressure
  7. Halloween: How did we fall in love with pumpkins? – BBC News
  8. WWE star Jimmy Uso arrested in Detroit after alleged drunken altercation with police: report
  9. Thousands who had surgery on broken bones face having their metal plates removed
  10. Five Places to Visit in New Orleans
  11. Fairfax accuser also says she was raped by former NBA player Corey Maggette
  12. Tinder, Grindr and other dating apps failed to protect children from sexual exploitation, report says
  13. Kamala Harris says she listened to Snoop Dogg, Tupac while smoking weed in college years before they made music
  14. Pair of Parliamentary committees urge the UK statistics watchdog to fix RPI as soon as possible
  15. Boards must have women – California law: BBC News Review
  16. Valentine’s Day movies on Netflix: THESE are the best Valentine’s Day movies to stream NOW | Films | Entertainment
  17. Miracle treatment or dangerous drug? Indonesian growers cash in on Kratom as it takes hold in the US
  18. 9 affordable US vacation spots for 2019
  19. Liverpool 3-0 Bournemouth AS IT HAPPENED: Mohamed Salah on target as Reds go three clear | Football | Sport
  20. Richard Branson says he’ll fly to space by July
  21. Ghost news: OAP forced to move into Travelodge after being haunted
  22. Brexit: Seaborne Freight no-deal ferry contract scrapped
  23. Mortgage deals get cheaper for low-deposit homebuyers as increased competition sees rates fall
  24. Terry Crews claims National Enquirer owner tried to ‘silence’ him with false prostitutes stories
  25. Yoga could help millions of arthritis patients
  26. Vonn shows off bruises after horror crash in skiing world championships
  27. Telemedicine’s challenge: Getting patients to click the app
  28. Bible news: Prophecy ‘FULFILLED’ after secret code cracked by experts
  29. How the world reacted to Trump’s speech
  30. FTSE LIVE: Barratt shrugs off Brexit pressures; Interserve agrees rescue deal to slash debt pile
  31. Anger on streets over royal wedding row – BBC News
  32. Izzy Young, who organized Bob Dylan’s first big concert, dead at 90
  33. Super Bowl LIII diets, splurges and fan snacks, revealed
  34. A380 future in doubt as Airbus meets with Emirates
  35. Top NFL awards go to Mahomes, Nagy, Luck, Barkley, Long
  36. The science of salting roads: How city streets are being kept safe
  37. Bible scholars ‘find Red Sea crossing site from Egypt to Saudi Arabia’
  38. Former Virginia Gov. McAuliffe calls on Northam to resign amid yearbook photo scandal
  39. Jamal Khashoggi’s fiancee on his murder – BBC News
  40. Pete Davidson, Kate Beckinsale spotted leaving LA comedy club together after comedian’s performance
  41. ‘It’s very hard to tell parents their child is no more’, reveals paediatric heart surgeon
  42. 5 Places to Visit in Ketchum, Idaho
  43. Transfer news LIVE: Carrasco to Arsenal, Newcastle SIGN Almiron, Man Utd announce Martial | Football | Sport
  44. Army tests new communication device that could save wounded soldiers’ lives
  45. Objectophilia: Woman says her boyfriend is a Boeing 737 named Schatz
  46. Brexit: ‘Extra time’ may be needed, says Jeremy Hunt
  47. Shares in Metro Bank down over 12% amid accounting error saga
  48. BBC News Review: Bangladesh’s missing millions
  49. Can You Ever Forgive Me review: Melissa McCarthy gives Oscar-worthy performance | Films | Entertainment
  50. Hypochondriacs who rely on data from their Fitbits ‘are piling extra pressure on the NHS’
  51. TSA officers get partial pay as shutdown’s financial toll worsens
  52. TRANSFER NEWS LIVE: All the deals from the Premier League and Europe
  53. Stressful jobs DO cause weight gain – but only in women
  54. Alien news: Huge sinkholes appear at the same time as mysterious lights
  55. Booker heading to Iowa in October
  56. BBC World News – Focus on Africa
  57. Pop star Kelsy Karter gets Harry Styles inked on her cheek
  58. A woman’s hair extension had to be surgically removed from her face after she was stabbed in the eye
  59. Going ‘Home’ When You’re an Immigrant
  60. Body of Chris Brown, former champion surfer, found washed up on California shore, police say
  61. Mars blast! Stunning new impact crater spotted on the Red Planet
  62. Weirdest items doctors have removed from people’s bottoms
  63. Experts say Trump’s border wall will take years longer than he claims
  64. A 1978 Ford Fiesta NEVER driven on the road to be sold at H&H auction
  65. BBC News Review: Hillary Clinton’s illness
  66. Nintendo Switch games UPDATE: Metroid Prime 4 release date DELAY revealed | Gaming | Entertainment
  67. US insulin costs per patient nearly DOUBLED from 2012 to 2016
  68. Transfer news LIVE: Arsenal boss unhappy, Man Utd hope, Liverpool, Chelsea, Leeds latest | Football | Sport
  69. ‘Supercooled’ bottles of water INSTANTLY turn rock hard when banged on a table
  70. Alien news: Fears end is near after light in night sky sparks outage
  71. Colorado state lawmaker says blacks, whites lynched ‘in nearly equal numbers’ for being Republican
  72. FTSE LIVE: Pound rises on strong wage data
  73. BBC World News 25th anniversary – BBC News
  74. Meghan Markle held a secret meeting with New Zealand Prime Minister Jacinda Ardern
  75. The Sackler family wanted to sell OxyContin as an UNCONTROLLED substance, court documents allege
  76. Russian hackers, firewall check-ups and more: Tech Q&A
  77. Super blood wolf moon ECLIPSE in January is ‘harbinger of apocalypse’
  78. Brexit: Theresa May should become mediator, says Sir John Major
  79. Pound’s Brexit plunge pushes car insurance premiums higher for first time since early 2017
  80. Hinglish taught in UK ‘for first time’ – BBC News
  81. Fortnite event COUNTDOWN: Start time, Ice King storm sphere, Twitch live stream, season 7 | Gaming | Entertainment
  82. Man, 33, injected himself with his own SEMEN to treat back pain
  83. Grounded new planes, routes, safety inspections
  84. Ex-NFL Pro Bowl wide receiver details past relationship with Jeff Bezos’ girlfriend Lauren Sanchez
  85. YouTube warns against Bird Box-style prank videos risky memes rage
  86. Ghost news: Man left TERRIFIED after re-watching video of him entering house
  87. New sexual misconduct allegations emerge against CBS boss
  88. Education publishing group Pearson sees share price fall 6%
  89. ‘Star Wars 9’ teased by John Boyega with bloody on-set photo
  90. War on sale of treats: Sweet ban in obesity fight
  91. Tottenham 0-0 Man Utd LIVE: Score and Premier League latest, Paul Pogba & Harry Kane start | Football | Sport
  92. 15 amazing Google tricks you never knew before now
  93. California Gov Gavin Newsom pledges unemployment benefits to furloughed federal workers
  94. Can ageing be delayed, stopped or even reversed? BBC News
  95. Kate Middleton’s brother James Middleton reveals secret battle with depression
  96. Scientists prove men are more sensitive to pain than women
  97. Spanish Civil Guard make 15 arrests following investigation into tennis match-fixing
  98. The future of driving: Audi puts VR games in every car as autonomous vehicles are unveiled at CES
  99. Blood Moon 2019: What is Blood Moon prophecy? Is Super Blood Wolf Moon sign of end times?
  100. Bernie Sanders’ 2016 presidential adviser accused of sexual assault
  101. Ford to cut thousands of jobs across Europe as it seeks to cut costs
  102. Is Donald Trump a danger to national security? BBC News
  103. Fortnite gnomes: ALL chilly gnomes map locations, week 6 challenge guide | Gaming | Entertainment
  104. 30million NHS consultations could be conducted through Skype-style videos
  105. Five Carry-On Essentials for Travelers Who Love to Pack Light
  106. Charles Barkley compares NBA All-Star Game fan voting to presidential election
  107. As CES kicks off, home items are getting smarter and creepier, like it or not
  108. Mutant one-eyed cow worshipped ‘as a GOD’ after ‘miracle’ birth
  109. Brexit: PM ‘working to get further EU assurances’
  110. How much money do I need to save for my pension?
  111. Canada officially apologises: BBC News Review
  112. Meghan Markle’s father says he’s ‘very upset’ by alleged Kate Middleton feud: ‘They should put their differences aside’
  113. Retiring abroad in 2019? Consider these top 5 locations
  114. China releases 308lb rover named Jade Rabbit 2 to trundle across the far side of the moon
  115. Elvis alive? Tape of the King speaking ‘four years AFTER death’ REVEALED
  116. Pelosi: ‘Open discussion’ on whether Trump could be indicted in office
  117. UK’s largest online musical instrument and equipment specialist Gear4music sees shares halve
  118. MyHeritage DNA on BBC world news
  119. ATLAS game update: Patch notes and server status latest revealed by Studio Wildcard | Gaming | Entertainment
  120. US set for unprecedented outbreak of mysterious polio-like virus in 2020
  121. Steelers star Antonio Brown benched after dispute with Ben Roethlisberger, report says
  122. Facebook’s Zuckerberg blasted for ‘out of touch’ year-end post after scandal-plagued 2018
  123. End of the World: Rapture to start the apocalypse in 2019 says Bible
  124. Trump’s most memorable Twitter bombshells of 2018
  125. What will 2019 have in store for landlords?
  126. Reviving Italy’s ghost towns with an unusual hotel – BBC News
  127. Alexandra Richards gets engaged, dad Keith Richards and mom Patti Hansen ‘could not be happier’
  128. Measles fears in New Jersey airport
  129. U.S. airlines bristle at expansion of Qatar-backed Italian airline
  130. Andrew Strauss wife Ruth dies aged 46 after battling lung cancer
  131. Elon Musk asks judge to toss lawsuit filed by diver he called ‘pedo’
  132. Maine governor scribbles ‘stolen election’ on certificate confirming Democrat’s election win
  133. RAY MASSEY: Vauxhall’s grand design… I get behind the wheel of the first car I ever owned
  134. Is this safest place in the world? BBC News
  135. 14 Days of Fortnite: Christmas trees, goose nests, giant candy canes map locations | Gaming | Entertainment
  136. Prostate cancer: How to get involved
  137. 4 Men Held in Tourist Killings in Morocco. Denmark Calls It ‘Act of Terror.’
  138. Prolific streaker has pulled stunt more than 500 times across several sporting events
  139. Prolific streaker has pulled stunt more than 500 times across several sporting events
  140. Facebook’s lonely conservative takes on a power position
  141. ‘Wrong to ignore’ ethnicity of grooming gangs – Javid
  142. Thousands of bargain hunters queue from MIDNIGHT ahead of Boxing Day sales
  143. World’s oldest message in a bottle: BBC News Review
  144. Former ‘Apprentice’ star Elle Stevenson left ‘almost blind’ in brutal mugging
  145. Diabetic, 33, with erectile dysfunction hopes a ‘vampire penis injection’ will allow him to conceive
  146. London Gatwick drone sighting again shuts airport
  147. Transfer news LIVE: Bayern deal agreed, Man Utd demands, Arsenal, Liverpool, Barcelona | Football | Sport
  148. Apple may revamp the iPad Mini in 2019, report claims
  149. Alien news: Bizarre creature washes up on Australia
  150. Former Trump aides break their silence on Woodward book
  151. SUNDAY NEWSPAPER SHARE TIPS: Anglo Asian Mining, Gordon Dadds, Big Yellow and Dechra Pharma
  152. BBC World News – Channel Refresh
  153. Johnny Depp dropped from 'Pirates of the Caribbean' franchise, Disney producer confirms
  154. Sadiq Khan accused of being a ‘Scrooge’ for junk food advert ban
  155. Holiday cheer, history and great food in Berkeley Springs
  156. Kick It Out face questions over ‘serious incident at training day’
  157. DOJ charges Chinese nationals with ‘extensive’ hacking, stealing from tech companies, government agencies
  158. DOJ charges Chinese nationals for ‘extensive’ global hacking campaign
  159. Bank set to keep rates at 0.75% as Brexit uncertainty…
  160. When news goes wrong.. – BBC News
  161. Fortnite doorbell: How to complete ring doorbell week 3 season 7 challenge
  162. Mother and daughter with identical tumours are finally free of the painful growths
  163. If You Can’t Stop Name-Dropping, You’re Not Coming Skiing This Year
  164. Buffalo Bills’ Jerry Hughes gets his helmet stuck on teammate’s jersey
  165. Neil Armstrong’s boot sold for $48,000 as part of an out of this world ‘space auction’
  166. Tupac ALIVE? ’Security guard’ claims body double was used for cremation
  167. Dems, White House refuse to budge over border wall as Friday shutdown looms
  168. Shares in British retailers plunge after ASOS profit warning
  169. The Disruptors – BBC News
  170. Geoffrey Rush accused of inappropriate behavior by ‘Orange Is the New Black’ actress Yael Stone
  171. Baby who caught killer Ebola at just six days old is hailed a ‘miracle’
  172. Pep Guardiola finally dons Manchester City-themed Christmas jumper after not wearing one last year
  173. MIT develops incredible system to ‘shrink’ objects
  174. Bigfoot hunter spots pair of giant ‘red eyes’ lurking in forest
  175. Brexit: More assurances for MPs possible says May
  176. BBC News Review: Hong Kong riots
  177. ‘The Conners’ gets expanded second season at ABC: report
  178. Flu crisis: Number of people having flu jab at GP plummets
  179. Man Accused of Killing British Backpacker Grace Millane Appears in New Zealand Court
  180. Miami Dolphins’ Kenyan Drake wants ball he threw into stands after game-winning TD back
  181. Have you been naughty or nice? Santa ATM checks your TWEETS to decide
  182. Alien news: ‘Rod-shaped object’ BIGGER than Earth spotted moving past sun
  183. DNC chair praises George H.W. Bush: He ‘put country over party every day’
  184. Waitrose wounded as supermarket sales slow to lowest level in almost two years
  185. PM Modi To Inaugurate Tallest Statue In The World ‘Statue Of Unity’ Today | ABP News
  186. Fortnite update 7.01 Creative PATCH NOTES – New featured islands and building tools | Gaming | Entertainment
  187. Baby born after first ever womb transplant from dead donor is shown off by her proud parents
  188. Delta tests out offering most restrictive tickets to frequent flyers
  189. Credit card skimming on the rise as Indiana man gets arrested
  190. Cohen sentencing memo details efforts to help Trump 2016 campaign
  191. INVESTMENT EXTRA: Is it time to get away from travel company Thomas Cook?
  192. Syria air strikes: Latest updates- BBC News
  193. Trump voters were ‘gullible’ in 2016 election, NBC’s Chuck Todd says
  194. President Trump to attend Army-Navy football game Saturday in Philadelphia
  195. British Library to exhibit da Vinci’s notebooks
  196. Google Earth FRENZY as 'ancient megastructure' discovered on ocean floor
  197. How Avenatti’s 2020 aspirations fizzled: ‘Skeletons came to light’
  198. Maps reveal hidden truths of the world’s cities – BBC News
  199. Fortnite season 7 COUNTDOWN: Release date, start time, skins, snow map, servers, leaks | Gaming | Entertainment
  200. Mobile phones are seven times dirtier than TOILET SEATS, finds new study
  201. United Airlines inks deal with Avianca, Copa to grow in Latin America
  202. Raheem Sterling will keep improving, claims Man City teammate
  203. 5 ways to unearth incredible Amazon deals
  204. Antarctica bombshell as ‘pyramids and tunnels’ found on Google Earth
  205. Brexit: Gove warns of referendum if MPs don’t back PM’s deal
  206. Trump apologises to Kavanaugh: BBC News Review
  207. ‘Star Wars’ star Mark Hamill reacts to crime story about suspect named Luke Sky Walker
  208. Christmas recipes that are good for your GUT
  209. Purdue football coach’s high school alma mater receives threat after his decision to stay at school
  210. Dogs aren’t more clever than cats, says study
  211. Alien news: ‘Secret base’ spotted on MOON sparks frenzy
  212. Behind the scenes as the Kavanaugh nomination hit the rocks
  213. Car manufacturing in the UK has fallen again, dropping nearly 10 per cent last month
  214. Top 10: Latest international news and headlines from World
  215. Fortnite vehicle timed trials: ALL map locations for week 10 timed trials challenge | Gaming | Entertainment
  216. First gene-edited babies claimed in China
  217. A treasure trove of ancient history and culture
  218. Transfer news LIVE: Man Utd eye shock deal, Chelsea Hazard update, Arsenal bold move | Football | Sport
  219. Elon Musk thinks humans will have to merge with machines to overcome their ‘existential threat’
  220. Time travel PROOF? ‘Man from 2030’ reveals SHOCK US president
  221. Judge rejects Trump claim that he can’t be sued
  222. Almost one in four pubs have closed down since the financial crisis
  223. India: Has Narendra Modi lived up to expectations? BBC News
  224. Jerry Springer lands his own court show
  225. Stop panicking about indulgence on Thanksgiving
  226. Jane Maas, a Pioneer for Women in Advertising, Dies at 86
  227. Lennon ‘flattered’ by Ireland links but insists he’s happy at Hibs
  228. Share more DNA to protect your privacy in databases
  229. Life on Mars: Humans could look like ALIENS on Red Planet
  230. Catholic University dean resigns after questioning Kavanaugh accuser’s allegations that led to his suspension
  231. Richard Branson’s Virgin Atlantic in takeover talks with regional airline Flybe
  232. Is this the cheapest commute in the world? – BBC News
  233. Holiday Gift Guide 2018 – Best in home and productivity gadgets
  234. Internet may be fuelling hypochondria after ‘Google diagnoses’ surge by more than 8,700% in 3 years
  235. Airlines cancel thousands of flights after Avery surprises East Coast
  236. Kevin Durant slams Mavericks fan who shouted cupcake at him: ‘Watch the f—–g game and shut the f–k up’
  237. Cuomo rips New York Times, CNN, others, over Amazon’s $2.8B incentive package
  238. ISS 20th anniversary: Bizarre videos of ‘UFOs’ spark NASA COVER-UP
  239. Brexit deal: Business groups hit back at DUP’s Wilson
  240. Stopping the cyber-criminals: BBC News Review
  241. Martha Stewart shares her difficult first experience with Uber on social media
  242. Lifting weights for just five minutes can slash stroke and heart attack risk
  243. We’re Reimagining Our Travel Journalism. Tell Us What You’d Like to See.
  244. Why 536 AD was the worst year to be alive
  245. Great Pyramid of Giza: Egyptian Pharaoh ‘HIDDEN in secret chamber’
  246. How will Trump take Amazon move? ‘He will think Bezos made this decision to stick it to him.’
  247. SHARE PUNT OF THE WEEK: Pub chain Fuller’s
  248. Live Statue of Unity: Special coverage of inaugural of world’s tallest statue
  249. Jessie J ‘disappointed’ with fan comparisons to Channing Tatum’s ex Jenna Dewan
  250. NHS system error puts lives at risk as nearly 50,000 women are not sent screening letters
  251. Chiefs fans frustrated after NFL moves game vs. Rams from Mexico City to Los Angeles
  252. Bullets that don’t miss, weaponized insects and more: Innovations from DARPA, America’s secret lab
  253. Alien news: Oregon woman stunned as ’15 shape-changing UFOs’ appear
  254. Mattis heads to US-Mexico border to visit troops awaiting migrant caravan
  255. Telematics insurance has helped cut young driver casualties by a third
  256. Budget 2015 headlines in 4 minutes – BBC News
  257. Michael Douglas says famous dad Kirk Douglas told him his acting debut was ‘absolutely terrible’
  258. Now US regulators vow to ban menthol cigarettes
  259. West Ham midfielder Robert Snodgrass insists his side should be doing better this season
  260. Christian women in Ireland don’t believe in limbo anymore, survey finds
  261. Ancient Egypt bombshell: Shock evidence pyramids built 5,500 years early
  262. California’s Rohrabacher not conceding despite media’s call of Democrat victory
  263. Launch of dedicated ‘Poppy’ bank accounts gives boost for Armed Forces
  264. India’s campaigning Miss World – BBC News
  265. Red Dead Online release date: When does Red Dead Redemption 2 multiplayer come out? | Gaming | Entertainment
  266. Wynn Resorts shares fall 12 percent as it misses earnings estimates
  267. Several former NFL players win midterm races
  268. Facebook starts shipping Portal smart displays
  269. Alien news: Nazi technology ‘exposed as floating bell stuns locals’
  270. Prince Charles won’t speak out when he becomes king
  271. How do I vote if I own shares in a nominee account not paper?
  272. What if UK PM refused to allow another Scottish referendum? BBC News
  273. Legendary stuntwoman Kitty O’Neil dead at 72
  274. Opioid overdoses killed 200 Americans a DAY last year, DEA report reveals
  275. Transfer news LIVE: Neymar to Barcelona shock, Man Utd wage problem, Chelsea swap deal | Football | Sport
  276. Victorian street demolished in Second World War is found in Cornwall
  277. NASA spots huge ‘thermal anomaly’ in Atlantic Ocean sparking frenzy
  278. Avenatti stars in ‘avenging angel’ role
  279. Property prices pushed down by over valuations, a lack of supply and Brexit, say estate agents
  280. CEO Mette Hoffmann Meyer on BBC World News
  281. Jason Aldean, wife Brittany Kerr reveal daughter’s name at baby shower
  282. Phoenix Coldon’s mysterious disappearance perplexes retired officer in new doc: ‘I want to help bring some closure’
  283. Marsha Blackburn leads Phil Bredesen
  284. Is Russia still meddling in US politics? – BBC News
  285. Raheem Sterling arrives for Manchester City training with ‘Fully Paid’ hat
  286. Where to see the best fall foliage across the country
  287. New ‘sensitive’ cervical cancer screening could save women from smear tests after 55
  288. Alien news: UFO spotted ‘taking off from the moon’ in BOMBSHELL clip
  289. Sky finally launches Netflix via its Sky Q boxes
  290. John Schneider reveals ‘Dukes of Hazzard’ memories, weighs in on Tom Wopat troubles
  291. Angela Merkel’s political challenges – BBC News
  292. Essential Gear for Traveling Solo
  293. Paul Zimmerman, acclaimed NFL writer known as ‘Dr. Z,’ dead at 86
  294. Britain’s first double hand transplant patient can now open his door
  295. Ghost news: Man is ‘followed around haunted house by girl in a cape’
  296. Florida mayor accused of asking resident for sex in exchange for neighborhood speed bumps
  297. Is Mike Ashley King of the High Street? As he bags Evans Cycles, what else is in his retail empire?
  298. Kate Middleton reveals royal rule for Prince George, Princess Charlotte
  299. Trump says ‘no’ to migrants: BBC News Review
  300. Manchester United stars arrive for training ahead of Bournemouth clash
  301. NYC airport workers to earn nation’s highest minimum wage
  302. Costa Coffee stores BAN under 16s from buying caffeinated drinks
  303. Brexit Secretary ‘behaving like a thief in the night’
  304. Savills forecasts house prices will rise 15% in five years
  305. ‘Broad City’ star Ilana Glazer’s political event canceled after vandals write ‘kill all Jews’ inside synagogue
  306. World’s Tallest Statue Cost $420 Million, Tivals The Space Needle | NBC News
  307. The home of Bollywood has much to offer travelers
  308. NHL player Evander Kane facing $6M lawsuit as ex-girlfriend claims he reneged on $3M abortion payment
  309. Woman, 24, whose IBS left her looking ‘nine months pregnant’ is now a slim size 10
  310. Kasich: ‘A pox on both houses’ for Kavanaugh confirmation process
  311. Dumbo octopus monster SPOTTED by deep-sea EV Nautilus explorers
  312. Who is George Soros? – BBC News
  313. Dad creates VR world to help daughter – BBC News
  314. David Foster and Katharine McPhee show some PDA at Beverly Hills event
  315. DNA testing websites are ‘scaring women into asking for breast removal surgery’
  316. It Might Not Be a Drinking Problem, but It’s Definitely a Problem
  317. Commerce Department launches audit of steel tariff waivers
  318. Leicester helicopter crash: Schmeichel ‘stopped by police as he ran at burning helicopter’ | Football | Sport
  319. Michael Jackson ALIVE: Frenzy over King of Pop’s ‘nameless empty crypt’
  320. Meghan Markle, Prince Harry breaking royal protocol? 7 times the couple strayed from tradition
  321. ‘Heroic’ TSA agent saves man having heart attack at airport
  322. Hope for the millions of women with endometriosis as scientists edge one step closer to a ‘cure’
  323. Maxine Waters, Schiff among high-profile Dems poised to control committees if House flips
  324. Google Earth spots ‘secret spy plane’ in US military base near Area 51
  325. Parents are paying out thousands for their children to go on school trips
  326. The new MacBook Air makes it near impossible to eavesdrop
  327. Just FIVE percent of US children are meeting the recommended amount of weekly physical activity
  328. Brazilian airline Gol to offer premium class with no middle seats
  329. Retirement contribution limits will rise in 2019
  330. 5 things to binge-watch while spring cleaning
  331. No laughing matter: When exactly did clowns become scary?
  332. Vanessa Trump files for divorce from Donald Trump Jr
  333. Eyelid Lumps and Bumps
  334. 5 Ways Grains Interfere with Weight Loss
  335. Bright Eyes: More Than a Fresh Look
  336. Fighting the flu? This technology tries to help you get well faster
  337. Google hopes AI can predict heart disease by looking at retinas
  338. This startup wants to create a 3D-printed heart
  339. Expert SEO Advice on Marketing Your New Business
  340. Best Tools for Running a Retail Website
  341. How to Create an Exceptional Omnichannel Retail Experience
  342. Jimmie Johnson Mired in Career Worst 28-Race Losing Streak
  343. South Carolina Advances With 79-63 Win Over Buffalo
  344. Thomas Nears No. 1 With Another Short Round in Match Play
  345. Austin serial bomber: Self-described psychopath left behind unemotional trail of murder
  346. ‘Half my family is gone’: Mom mourns Iowa family found dead at Mexico resort
  347. March for our Lives rallies happening in every U.S. state: ‘We’re here and coming to make a change’
Sun, Feb 17, 2019
  1. Travelers are paying more to fly to Mexico and the Caribbean this year
  2. Images released of 12 men wanted over FA Cup violence before Millwall’s win over Everton last month
  3. Would you eat meat from a gene-edited animal?
  4. Alien news: UFO ‘not visible with naked eye’ filmed above Texas
  5. Border crossings at record lows as Trump moves to declare national emergency to build wall
  6. FTSE LIVE: RBS profits double; Premier Foods scraps Ambrosia sale; Pound under pressure
  7. Halloween: How did we fall in love with pumpkins? – BBC News
  8. WWE star Jimmy Uso arrested in Detroit after alleged drunken altercation with police: report
  9. Thousands who had surgery on broken bones face having their metal plates removed
  10. Five Places to Visit in New Orleans
  11. Fairfax accuser also says she was raped by former NBA player Corey Maggette
  12. Tinder, Grindr and other dating apps failed to protect children from sexual exploitation, report says
  13. Kamala Harris says she listened to Snoop Dogg, Tupac while smoking weed in college years before they made music
  14. Pair of Parliamentary committees urge the UK statistics watchdog to fix RPI as soon as possible
  15. Boards must have women – California law: BBC News Review
  16. Valentine’s Day movies on Netflix: THESE are the best Valentine’s Day movies to stream NOW | Films | Entertainment
  17. Miracle treatment or dangerous drug? Indonesian growers cash in on Kratom as it takes hold in the US
  18. 9 affordable US vacation spots for 2019
  19. Liverpool 3-0 Bournemouth AS IT HAPPENED: Mohamed Salah on target as Reds go three clear | Football | Sport
  20. Richard Branson says he’ll fly to space by July
  21. Ghost news: OAP forced to move into Travelodge after being haunted
  22. Brexit: Seaborne Freight no-deal ferry contract scrapped
  23. Mortgage deals get cheaper for low-deposit homebuyers as increased competition sees rates fall
  24. Terry Crews claims National Enquirer owner tried to ‘silence’ him with false prostitutes stories
  25. Yoga could help millions of arthritis patients
  26. Vonn shows off bruises after horror crash in skiing world championships
  27. Telemedicine’s challenge: Getting patients to click the app
  28. Bible news: Prophecy ‘FULFILLED’ after secret code cracked by experts
  29. How the world reacted to Trump’s speech
  30. FTSE LIVE: Barratt shrugs off Brexit pressures; Interserve agrees rescue deal to slash debt pile
  31. Anger on streets over royal wedding row – BBC News
  32. Izzy Young, who organized Bob Dylan’s first big concert, dead at 90
  33. Super Bowl LIII diets, splurges and fan snacks, revealed
  34. A380 future in doubt as Airbus meets with Emirates
  35. Top NFL awards go to Mahomes, Nagy, Luck, Barkley, Long
  36. The science of salting roads: How city streets are being kept safe
  37. Bible scholars ‘find Red Sea crossing site from Egypt to Saudi Arabia’
  38. Former Virginia Gov. McAuliffe calls on Northam to resign amid yearbook photo scandal
  39. Jamal Khashoggi’s fiancee on his murder – BBC News
  40. Pete Davidson, Kate Beckinsale spotted leaving LA comedy club together after comedian’s performance
  41. ‘It’s very hard to tell parents their child is no more’, reveals paediatric heart surgeon
  42. 5 Places to Visit in Ketchum, Idaho
  43. Transfer news LIVE: Carrasco to Arsenal, Newcastle SIGN Almiron, Man Utd announce Martial | Football | Sport
  44. Army tests new communication device that could save wounded soldiers’ lives
  45. Objectophilia: Woman says her boyfriend is a Boeing 737 named Schatz
  46. Brexit: ‘Extra time’ may be needed, says Jeremy Hunt
  47. Shares in Metro Bank down over 12% amid accounting error saga
  48. BBC News Review: Bangladesh’s missing millions
  49. Can You Ever Forgive Me review: Melissa McCarthy gives Oscar-worthy performance | Films | Entertainment
  50. Hypochondriacs who rely on data from their Fitbits ‘are piling extra pressure on the NHS’
  51. TSA officers get partial pay as shutdown’s financial toll worsens
  52. TRANSFER NEWS LIVE: All the deals from the Premier League and Europe
  53. Stressful jobs DO cause weight gain – but only in women
  54. Alien news: Huge sinkholes appear at the same time as mysterious lights
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A scientist claims to have helped create the world’s first genetically-modified humans during laboratory work in China.

The DNA of twin girls was altered with a powerful new tool capable of rewriting the very blueprint of life, Chinese researcher Dr He Jiankui says.

He claims the babies, named LuLu and Nana, were born a few weeks ago and have a resistance to infection with HIV, the AIDS virus.

A US scientist said he took part in the work in China, but this kind of gene editing is banned in the United States due to risks that altered DNA will warp other genes.

These potentially dangerous changes may then be passed down to future generations.

Gene editing is banned in Britain, the US many other parts of the world, and researchers said that, if Dr He’s claims are true, the ‘monstrous’ experiment was ‘not morally or ethically defensible.’

Scroll down for video 

He Jiankui speaks during an interview at a laboratory in Shenzhen in southern China’s Guangdong province. The Chinese scientist claims he helped make world’s first genetically edited babies: Twin girls whose DNA he claims to have altered

HOW DID DR HE DESCRIBE THE WORK? 

‘The gene editing occurred during IVF, or lab dish fertilisation.

‘First, sperm was ‘washed’ to separate it from semen, the fluid where HIV can lurk.

‘A single sperm was placed into a single egg to create an embryo.

‘Then the gene editing tool was added.

‘When the embryos were three to five days old, a few cells were removed and checked for editing.

‘Couples could choose whether to use edited or unedited embryos for pregnancy attempts.

‘In all, 16 of 22 embryos were edited, and 11 embryos were used in six implant attempts before the twin pregnancy was achieved.’

Dr Jiankui, of the Southern University of Science and Technology, in Shenzhen, said he altered embryos for seven couples during fertility treatments, with one pregnancy resulting thus far.

He said his goal was not to cure or prevent an inherited disease, but to try to bestow a trait that few people naturally have – an ability to resist infection with HIV.

He said the parents involved declined to be identified or interviewed, and would not say where they live or where the work was done.

There is no independent confirmation of Dr He’s claim, and it has not been published in a journal, where it would be vetted by other experts.

He announced the research Monday in Hong Kong to an organiser of an international conference on gene editing that is set to begin Tuesday, and earlier in exclusive interviews with The Associated Press.

‘I feel a strong responsibility that it’s not just to make a first, but also make it an example,’ he told the AP.

‘Society will decide what to do next’ in terms of allowing or forbidding such science.

Some scientists were astounded to hear of the claim and strongly condemned it.

It’s ‘unconscionable … an experiment on human beings that is not morally or ethically defensible,’ said Dr Kiran Musunuru, a University of Pennsylvania gene editing expert and editor of a genetics journal.

‘This is far too premature,’ said Dr Eric Topol, who heads the Scripps Research Translational Institute in California. ‘We’re dealing with the operating instructions of a human being. It’s a big deal.’

‘If true, this experiment is monstrous,’ said Professor Julian Savulescu, Director of the University of Oxford’s Uehiro Centre for Practical Ethics.

‘These healthy babies are being used as genetic guinea pigs. This is genetic Russian Roulette.’

However, one famed geneticist, Harvard University’s Professor George Church, defended attempting gene editing for HIV, which he called ‘a major and growing public health threat.’

‘I think this is justifiable,’ Professor Church said of that goal.

This image shows a microplate containing embryos that have been injected with Cas9 protein using the controversial gene editing tool Crispr. The image was taken at Dr He's laboratory in Shenzhen last month

This image shows a microplate containing embryos that have been injected with Cas9 protein using the controversial gene editing tool Crispr. The image was taken at Dr He’s laboratory in Shenzhen last month

In recent years scientists have discovered a relatively easy way to edit genes, the strands of DNA that govern the body.

The tool, called CRISPR-cas9, makes it possible to operate on DNA to supply a needed gene or disable one that’s causing problems.

It’s only recently been tried in adults to treat deadly diseases, with all edits confined to that person, meaning they cannot be passed down to their children.

Editing sperm, eggs or embryos is different – the changes can be inherited. 

In the US, it’s not allowed except for lab research. China outlaws human cloning but not specifically gene editing.

Dr He Jiankui (HEH JEE’-an-qway), who goes by ‘JK,’ studied at Rice and Stanford universities in the US before returning to his homeland to open a lab at Southern University of Science and Technology of China in Shenzhen, where he also has two genetics companies.

The DNA of twin girls was altered with a powerful new tool capable of rewriting the very blueprint of life, Chinenese researcher Dr He Jiankui says. Pictured id Dr He (left) with fellow researcher Zhou Xiaoqin at a laboratory in Shenzhen

The DNA of twin girls was altered with a powerful new tool capable of rewriting the very blueprint of life, Chinenese researcher Dr He Jiankui says. Pictured id Dr He (left) with fellow researcher Zhou Xiaoqin at a laboratory in Shenzhen

The US scientist who worked with him on this project after Dr He returned to China was physics and bioengineering Professor Michael Deem, who was his adviser at Rice in Houston.

Professor Deem also holds what he called ‘a small stake’ in – and is on the scientific advisory boards of – Dr He’s two companies.

The Chinese researcher said he practiced editing mice, monkey and human embryos in the lab for several years and has applied for patents on his methods.

Dr He said he chose to try embryo gene editing for HIV because these infections are a big problem in China.

He sought to disable a gene called CCR5 that forms a protein doorway that allows HIV, the virus that causes AIDS, to enter a cell.

WHAT ARE SOME OF THE DOUBTS SURROUNDING DR HE’S CLAIMS?

Several scientists reviewed materials that Dr He provided to the AP and said tests so far are insufficient to say the editing worked or to rule out harm.

They also noted evidence that the editing was incomplete and that at least one twin appears to be a patchwork of cells with various changes.

‘It’s almost like not editing at all’ if only some of certain cells were altered, because HIV infection can still occur, famed Harvard University geneticist Professor George Church said.

Church and Dr Kiran Musunuru, a University of Pennsylvania gene editing expert, questioned the decision to allow one of the embryos to be used in a pregnancy attempt, because the Chinese researchers said they knew in advance that both copies of the intended gene had not been altered.

‘In that child, there really was almost nothing to be gained in terms of protection against HIV and yet you’re exposing that child to all the unknown safety risks,’ Dr Musunuru said.

The use of that embryo suggests that the researchers’ ‘main emphasis was on testing editing rather than avoiding this disease,’ Church said.

Even if editing worked perfectly, people without normal CCR5 genes face higher risks of getting certain other viruses, such as West Nile, and of dying from the flu. 

Since there are many ways to prevent HIV infection and it’s very treatable if it occurs, those other medical risks are a concern, Dr Musunuru said.

There also are questions about the way Dr He said he proceeded.

He gave official notice of his work long after he said he started it – on November 8, on a Chinese registry of clinical trials.

It’s unclear whether participants fully understood the purpose and potential risks and benefits.

For example, consent forms called the project an ‘AIDS vaccine development’ program.

All of the men in the project had HIV and all of the women did not, but the gene editing was not aimed at preventing the small risk of transmission, Dr He said.

The fathers had their infections deeply suppressed by standard HIV medicines and there are simple ways to keep them from infecting offspring that do not involve altering genes.

Instead, the appeal was to offer couples affected by HIV a chance to have a child that might be protected from a similar fate.

Dr He recruited couples through a Beijing-based AIDS advocacy group called Baihualin.

Its leader, known by the pseudonym ‘Bai Hua,’ told the AP that it’s not uncommon for people with HIV to lose jobs or have trouble getting medical care if their infections are revealed.

The researchers used a gene-editing tool called CRISPR-cas9 for their experiment, which makes it possible to operate on DNA. This image shows a video feed of a researcher in Dr He's team using the tool under a microscope

The researchers used a gene-editing tool called CRISPR-cas9 for their experiment, which makes it possible to operate on DNA. This image shows a video feed of a researcher in Dr He’s team using the tool under a microscope

Describing the work, Dr He said: ‘The gene editing occurred during IVF, or lab dish fertilisation.

‘First, sperm was ‘washed’ to separate it from semen, the fluid where HIV can lurk. A single sperm was placed into a single egg to create an embryo. Then the gene editing tool was added.

‘When the embryos were three to five days old, a few cells were removed and checked for editing.

‘Couples could choose whether to use edited or unedited embryos for pregnancy attempts.

‘In all, 16 of 22 embryos were edited, and 11 embryos were used in six implant attempts before the twin pregnancy was achieved,’ Dr He said.

WHAT IS CRISPR-CAS9?

CRISPR-Cas9 is a tool for making precise edits in DNA, discovered in bacteria.

The acronym stands for ‘Clustered Regularly Inter-Spaced Palindromic Repeats’.

The technique involves a DNA cutting enzyme and a small tag which tells the enzyme where to cut.

The CRISPR/Cas9 technique uses tags which identify the location of the mutation, and an enzyme, which acts as tiny scissors, to cut DNA in a precise place, allowing small portions of a gene to be removed

The CRISPR/Cas9 technique uses tags which identify the location of the mutation, and an enzyme, which acts as tiny scissors, to cut DNA in a precise place, allowing small portions of a gene to be removed

By editing this tag, scientists are able to target the enzyme to specific regions of DNA and make precise cuts, wherever they like.

It has been used to ‘silence’ genes – effectively switching them off.

When cellular machinery repairs the DNA break, it removes a small snip of DNA.

In this way, researchers can precisely turn off specific genes in the genome.

The approach has been used previously to edit the HBB gene responsible for a condition called β-thalassaemia. 

Tests suggest that one twin had both copies of the intended gene altered and the other twin had just one altered, with no evidence of harm to other genes, Dr He said. 

People with one copy of the gene can still get HIV, although some very limited research suggests their health might decline more slowly once they do.

Several scientists reviewed materials that Dr He provided to the AP and said tests so far are insufficient to say the editing worked or to rule out harm.

They also noted evidence that the editing was incomplete and that at least one twin appears to be a patchwork of cells with various changes.

‘It’s almost like not editing at all’ if only some of certain cells were altered, because HIV infection can still occur, Church said.

Zhou Xiaoqin removes the cryostorage sheath from a container for an embryo at Dr He's laboratory in Shenzhen in southern China's Guangdong province

Zhou Xiaoqin removes the cryostorage sheath from a container for an embryo at Dr He’s laboratory in Shenzhen in southern China’s Guangdong province

Church and Musunuru questioned the decision to allow one of the embryos to be used in a pregnancy attempt, because the Chinese researchers said they knew in advance that both copies of the intended gene had not been altered.

‘In that child, there really was almost nothing to be gained in terms of protection against HIV and yet you’re exposing that child to all the unknown safety risks,’ Musunuru said.

The use of that embryo suggests that the researchers’ ‘main emphasis was on testing editing rather than avoiding this disease,’ Church said.

Even if editing worked perfectly, people without normal CCR5 genes face higher risks of getting certain other viruses, such as West Nile, and of dying from the flu. 

In this image an embryo is injected with proteins using the controversial Crispr-Cas9 technique

In this image an embryo is injected with proteins using the controversial Crispr-Cas9 technique

Since there are many ways to prevent HIV infection and it’s very treatable if it occurs, those other medical risks are a concern, Musunuru said.

There also are questions about the way Dr He said he proceeded.

He gave official notice of his work long after he said he started it – on November 8, on a Chinese registry of clinical trials.

It’s unclear whether participants fully understood the purpose and potential risks and benefits.

For example, consent forms called the project an ‘AIDS vaccine development’ program.

The Rice scientist, Professor Deem, said he was present in China when potential participants gave their consent and that he ‘absolutely’ thinks they were able to understand the risks.

WHAT IS EPIGENETICS?

Epigenetics is a field of molecular science which involves altering the expression of certain genes. 

It is defined as: ‘The study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.’

Instead of changing the genes present in a living thing, it changes which of its genes are ‘turned on’. 

Although it is the genetic code which forms the foundations for every living organism, it is the combination of activated genes which defines it.

This gene expression can be complex or simple and can control a wide range of features. 

As some features and behaviours are controlled by single genes, these can be easily altered by turning this gene off, for example. 

Some genes inhibit growth and limit cell proliferation, by deactivating these genes things can be grown which do not have the same natural limitations as before. 

This can, and has, led to larger, and bigger foods – mainly seen in the fruit and vegetable sector.

The process is completely harmless, as it does not introduce any artificial or ‘unnatural’ products. 

One of the most common forms of epigenetics is Crispr-Cas9, which is a specific technique that can edit, activate or deactivate cell.

Professor Deem said he worked with Dr He on vaccine research at Rice and considers the gene editing similar to a vaccine.

‘That might be a layman’s way of describing it,’ he said.

Both men are physics experts with no experience running human clinical trials.

The Chinese scientist, Dr He, said he personally made the goals clear and told participants that embryo gene editing has never been tried before and carries risks. 

Dr He said he also would provide insurance coverage for any children conceived through the project and plans medical followup until the children are 18 and longer if they agree once they’re adults.

Further pregnancy attempts are on hold until the safety of this one is analyzed and experts in the field weigh in, but participants were not told in advance that they might not have a chance to try what they signed up for once a ‘first’ was achieved, Dr He acknowledged.

In this photo, Zhou Xiaoqin (left) loads Cas9 protein and PCSK9 sgRNA molecules into a fine glass pipette as Qin Jinzhou watches

In this photo, Zhou Xiaoqin (left) loads Cas9 protein and PCSK9 sgRNA molecules into a fine glass pipette as Qin Jinzhou watches

Free fertility treatment was part of the deal they were offered.

Dr He sought and received approval for his project from Shenzhen Harmonicare Women’s and Children’s Hospital, which is not one of the four hospitals that Dr He said provided embryos for his research or the pregnancy attempts.

Some staff at some of the other hospitals were kept in the dark about the nature of the research, which Dr He and Professor Deem said was done to keep some participants’ HIV infection from being disclosed.

‘We think this is ethical,’ said Lin Zhitong, a Harmonicare administrator who heads the ethics panel.

Any medical staff who handled samples that might contain HIV were aware, Dr He said. 

An embryologist in Dr He’s lab, Qin Jinzhou, confirmed to the AP that he did sperm washing and injected the gene editing tool in some of the pregnancy attempts.

The study participants are not ethicists, Dr He said, but ‘are as much authorities on what is correct and what is wrong because it’s their life on the line.’

‘I believe this is going to help the families and their children,’ Dr He said.

If it causes unwanted side effects or harm, ‘I would feel the same pain as they do and it’s going to be my own responsibility.’



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